Tuesday, January 6, 2015

Electronic nicotine delivery systems: emerging science foundation for policy

J E Henningfield, G S Zaatari

The US Food and Drug Administration (FDA) conducted preliminary tests of several electronic nicotine delivery system (ENDS) models, documenting widely varying levels of nicotine, carcinogens and diethylene glycol, which it noted "is toxic to humans. The FDA concluded that "quality control processes used to manufacture these products are inconsistent or non-existent because of variability in contents and emissions.
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An additional complication is that ENDS might produce substantially higher deliveries if they are "spiked with nicotine liquid" available for refilling their cartridges (eg, Totally Wicked ELiquid Smoke Juice). ENDS refill products raise many of the same safety and effectiveness issues as ENDS. A cursory review of such products on the Internet revealed a broad range of refill products, claims and even warnings, with some admitting carcinogens and the possibility of nicotine poisoning (some appear to contain sufficient nicotine to kill many persons even if simply spilled on the skin). It would seem that where the nicotine is intended for human consumption, it should be subject to the same regulations for safety and effectiveness as drugs including standards for child-resistant packaging and labelling to minimise risk of poisoning. read more

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